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References Bunchorntavakul, C

Gut microbiome structural changes determined by deep sequencing shotgun metagenomics Consistent with the finding of reduced bacterial richness and diversity in DIO mice, gene richness was lower in all DIO mouse groups (average 530,000560,000 genes) compared to chow-fed mice (average 630,000 genes)

Based on the structural mechanism studies of GLP-1, Tirzepatide, Danuglipron, LY3502970, and TT-OAD2 involved in GLP-1R receptor recognition, the binding pockets for Danuglipron, LY3502970, and TT-OAD2 are distinctly different: only three residues interact with all three compounds, thirteen residues interact with two of the three compounds, and twenty-two residues only interact with one of the compounds

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