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65 Despite efforts have been made to repair mtDNA with various mechanisms, the mutation rate of mtDNA remains higher than nuclear DNA

Disruption of this axis (e.g., gut dysbiosis reducing SCFA production) is closely associated with MDD, as shown by reduced SCFA levels and altered microbiota composition (e.g., decreased Bifidobacterium ) in depressed patients (23, 24)

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Total serum copper is not a reliable diagnostic in Wilson disease because it includes both ceruloplasmin-bound copper (low in Wilson disease, proportional to low ceruloplasmin) and free copper, which is elevated

Despite having the lowest TPC among the species tested, the acetone extract of E