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These trends support the interpretation of statistically significant biochemical shifts as modulation of metabolic processes rather than clinically adverse events

Repeat fasting glucose and lipids at 12 weeks after GLP-1 initiation

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The Reuters report on a head-to-head trial against tirzepatide (February 2026) noted CagriSema did not meet a non-inferiority threshold against tirzepatide on average weight loss at 84 weeks