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The fixed-effect sensitivity analysis preserved the overall directional ordering, supporting the robustness of the main interpretation (Supplementary Appendix 6)

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About CT-996 study 6 The CT-996-201 trial (NCT05814107) is a multi-part, multi-cohort Phase I randomised, double-blind, placebo-controlled, single- and multiple- ascending dose study designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of CT-996 in otherwise-healthy adults who are overweight or obese, with and without type 2 diabetes

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