Managing water retention Diet plays a significant role
This is one reason the safety and side effect profile of GH secretagogues tends to be more favourable than that of exogenous HGH, particularly regarding IGF-1 overshoot and glucose dysregulation
An improved HPLC measurement for GSH and GSSG in human blood
Reported Side Effects: Injection site reactions (most common) Headache Mild water retention Transient dizziness Fatigue (temporary) Joint stiffness (with GH elevation) Rare/Serious (requiring immediate attention): Significant swelling of hands, feet, or face Chest pain or shortness of breath Vision changes Allergic reactions FDA Concerns: Immunogenicity risk Limited clinical safety data Classified as Category 2 bulk drug substance presenting significant safety risks Regulatory Status United States: Not FDA approved for any indication
Softer, more hydrated skin usually appears within the first month, while clearer overall brightening typically develops by month 2 to 3 of consistent treatment
Sci China Mater, 2024, 67: 30963105 Arshad F, Sk MP