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However, comparable stability was also observed for similar experimental composites with Cu-MBGN: no deterioration in flexural strength after 28 days of water storage 9 , a higher cross-linking density of the polymer network and a significantly lower release of monomers compared to the composites with inert fillers or 45S5 22

Evidence strength: Weak to moderate

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TB-500 also appears to be generally well-tolerated, but again, safety data derived from adequately powered clinical trials is lacking