Acknowledgements We are grateful to Tibor Pli and Andrs Dr from the Institute of Biophysics, HUN-REN Biological Research Centre for providing access to the spectrofluorometer Fluorolog 3 (Horiba Jobin Yvon) and to the Malvern Zetasizer Nano ZS device (Malvern Instruments)
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Quality assessment of the included studies The risk of bias in random sequence generation and allocation is low in most trials, while the risk of participant and staff blinding varies
Its a gradual accumulation of pigment that builds over weeks and months
Depression in Alzheimer's disease: epidemiology, mechanisms, and treatment
The peptide upregulates tyrosinase, but the enzyme needs UV-induced oxidative stress to catalyze pigmentation