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Free Radic Biol Med 63:187194

These factors, including lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF-), and interleukin-1 beta (IL-1), may impede P-gp activity, activate the mitogen-activated protein kinase (MAPK) signaling pathway, and increase nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) expression in ECs

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[14] [15] [16] In the final step of the biosynthesis, two molecules of 6,7-dimethyl-8-ribityllumazine are combined by the enzyme riboflavin synthase in a dismutation reaction