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Microarray and transcriptomic analyses have shown that GHK-Cu modulates the expression of hundreds of genes in human fibroblasts, with research interest in understanding which regulatory networks are engaged

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According to American Gastroenterological Association guidelines, osmotic laxatives like polyethylene glycol (PEG 3350) are recommended as first-line treatment for tirzepatide-induced constipation, as they are generally safe for regular use and effectively draw water into the colon to soften stools

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