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These pharmacokinetic characterisation studies established Mod-GRF 1-29 as the short-acting GHRH analogue of choice for research applications requiring pulsatile GH release patterns, and documented its full GHRH-R agonism and cAMP-driven somatotroph activation equivalent to native GHRH

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To understand the mechanism underlying the role of MOTS-c in protecting pancreatic islets from senescence, we performed gene microarray analyses in pancreatic islet cells treated with either MOTS-c or a scrambled peptide