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Estimated two-year mortality rates with 95% confidence intervals were as follows (Figure 1): 13.1% (11.8%-14.6%) for patients prescribed both GLP-1 RA and SGLT2i 17.8% (16.6%-19.1%) for GLP-1 RA only 20.6% (19.5%-21.8%) for SGLT2i only 28.1% (27.7%-28.4%) for neither Prescription rates at the time of HF admission evolved as follows (Figure 2): January 2018: GLP-1 RA 0.9%, SGLT2i 0.5%, both 0.0%, neither 98.6% December 2024: GLP-1 RA 13.6%, SGLT2i 18.7%, both 6.3%, neither 74.0%

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Unexpectedly, this activation was rapidly reduced after PH in Gstp1/2 / mice

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