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Here, we sought to address this knowledge gap by modelling the trafficking and signalling behaviours of GLP-1R phospho-site null mutants in pancreatic -cells, uncovering the C-terminal Ser451/452 doublet as critical for the recruitment of GRK2 to the receptor, and revealing an unexpected positive correlation between GLP-1R phosphorylation and -cell cAMP production following receptor activation by its natural ligand, GLP-1
The cohort was divided into two groups: the GLP-1 RAs users group ( n = 7,511), and the GLP-1 RAs non-users group ( n = 158,349)
MB participated in the design of the study and commented on the manuscript