Cardiovascular events, such as hypertension, edema, and in rare cases myocardial infarction or stroke, appear related to prostaglandin imbalance and fluid retention
MET=metformin
Two collagen types dominate: Type I collagen (mature tendon structure) Type III collagen (early repair phase) In rodent studies, BPC-157-treated tendons showed: Increased type I collagen deposition Improved fiber parallel alignment Better biomechanical strength This suggests influence over: TGF- signalling Matrix metalloproteinases (MMPs) Extracellular matrix remodelling enzymes Balanced ECM remodelling prevents disorganized scar tissue
Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney Jr JF, Vita JA
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GeroScience 39 , 129145 (2017)
