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In vitro human plasma stability Human plasma was preheated at 37 C for 15 min before being spiked with a final concentration of 0.25 mM of the peptide or conjugate
Fragmentation with staphylococcal protease results in GIP1-3 and GIP4-42, fragmentation with enterokinase in GIP1-16 and GIP17-42
For instance, macrophage-engineered exosomes loaded with GLP-1-encoding mRNAs promoted endogenous peptide production and glycemic normalization in diabetic models with minimal systemic immune activation [117]
Aviles-Olmos I, Dickson J, Kefalopoulou Z, Djamshidian A, Ell P, Soderlund T, et al
W.et al (2021)