We have solved the structures of the pi class GST hP1-1 in complex with its substrate, glutathione, a transition-state complex, the Meisenheimer complex, and an inhibitor, S-(rho-bromobenzyl)-glutathione, and refined them to resolutions of 1.8 A, 2.0 A and 1.9 A, respectively
several are on the FDA's "difficult to compound" or "do not compound" lists [13]
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It is currently in clinical trials for the treatment of inflammatory bowel disease
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