According to NICE guidelines (NG28), GLP-1 receptor agonists may be considered for type 2 diabetes when metformin and other treatments have not achieved glycaemic targets
For example, in the SURMOUNT-4 trial, participants who continued tirzepatide treatment experienced further weight reduction, while those who switched to a placebo saw weight regain
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[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Sharma R, Ramanathan A
However, the intravenous route should only be used under medical supervision, as inappropriate administration can cause rare but serious complications
