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The genetic correlates relate primarily to variants in the genes coding for transporters controlling plasma UA, yet such presumed functional variants will also influence, through the same proteins, the transport of UA into the brain and subsequently into neurons and glia, as described below

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In a sensitivity analysis excluding the SELECT trial, which was the only study enrolling pre-diabetic participants, the reduction in MACE remained consistent (HR (95% CI): 0.87(0.820.93)

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