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Int J Mol Sci 21(13):4777 Hernndez Cordero AI, Yang CX, Yang J, Horvath S, Shaipanich T, MacIsaac J, Lin DTS, Kobor MS, Guillemi S, Harris M, Lam W, Lam S, Montaner J, Man SFP, Sin DD, Leung JM (2022) Airway aging and methylation disruptions in HIV-associated chronic obstructive pulmonary disease