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Further, we were unable to replicate the p values for three studies [46, 47, 87]

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See Pros and Cons of Using PRP for Tendon Injuries Prolotherapy This treatment involves administering small amounts of a medicated solution, such as dextrose or saline, into the rotator cuff tissue(s) over a period of several weeks with the goal of inducing tissue regeneration, promoting healing, and reducing pain

These findings are consistent with clinical observations from practitioners who report visible improvements in wound healing within the first one to two weeks of treatment