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Normally, NF-B is bound to its inhibitor IkB, thus remaining confined to the cytoplasm: to be activated NF-B is phosphorylated by the IB kinase (IKK) complex, which leads to the IkB degradation and allows the transcription factor translocation into the nucleus [117]

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A rat primary hepatocyte culture model for aging studies

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In this regard, until recently, glutathione could only be effectively taken by injection: the oral route has always been a strong limit for its absorption, so much so as to be practically discarded