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In clinical trials, people taking GLP-1 medications for obesity lost an average of 5-15% of their body weight over a period of 6-12 months, which is about 5 times the amount of weight loss through diet and exercise alone

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern

This may be related to curcumins effect on GLP-1

A mix of cardio and weight training could help increase your levels

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