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Neurotrophic pathways: BDNF, NGF, HGF and molecular logic Most modern cognitive peptides converge on three main trophic pathways: BDNF / TrkB BDNF is the most studied trophic molecule in adult neuroplasticity

355 Moreover, TDP-43 aggregates can translocate into mitochondria, triggering mitochondrial DNA release into the cytoplasm and activating inflammatory signaling through the cGAS-STING pathway

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As we age, our NAD levels naturally decline