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Specifically, GLP-1 receptor activation increases intracellular cAMP levels, which in turn activates protein kinase A (PKA)

Mi Y, et al

Details on the statistical analyses of the fMRI data are provided in the Supplemental Methods

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In the pivotal STEP-1 trial , participants receiving once-weekly Semaglutide injections lost an average of 14.9% of their baseline body weight over 68 weeks , compared to just 2.4% in the placebo group