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Central tolerance is mediated in part by the transcription factor AIRE (autoimmune regulator), which promotes expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells, allowing negative selection of high-avidity self-reactive T cells

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In the presence of UVR, reduced folates may undergo irreversible oxidative cleavage into by-products of pteridine and p-aminobenzoylglutamate, both of which lack vitamin activity

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