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Figure 3 4 Targeting lipid metabolism for DKD treatment 4.1 Conventional drugs 4.1.1 Atorvastatin Atorvastatin effectively reduced the levels of low-density lipoprotein CHOL (LDL-C), creatinine (CREA), and urinary albumin and creatinine (UACR) and downregulated the expression of the inflammatory factors TNF-, monocyte chemoattractant protein-1 (MCP-1), and IL-6 expression in renal tissues, which ameliorates renal injury and delays the progression of DKD by reducing morphological lesions and renal fibrosis and increases transforming growth factor beta (TGF-) and collagen I staining (185)

People with autoimmune diseases may experience unpredictable inflammatory responses

They improve insulin sensitivity : By making your cells more responsive to insulin, they help break the insulin resistance cycle driving your PCOS

Adapted from KDIGO 2022 [81]

Caetano-Silva ME, Rund LA, Vailati-Riboni M et al (2021) Copper-binding peptides attenuate microglia inflammation through suppression of NF-kB pathway

facility Accompanied by a Certificate of Analysis (COA) Verified via HPLC and mass spectrometry Shipped securely with quality-control documentation Contents: 10mg Thymalin lyophilized peptide Appearance: White to off-white crystalline powder Solubility: Reconstitute with sterile bacteriostatic water Storage: Store lyophilized at -20C