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Bone loss during the fat loss period (fat loss model in obese rats) Experimental Design: Animals: Obese SD rats induced by high-fat diet were randomly divided into an obesity control group, a simple weight loss group (30% calorie restriction), and a weight loss+AOD 9604 group (500 g/kg/day)

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(Nature Communications) demonstrated that selective NNMT inhibition in diet-induced obese mice produced significant reductions in fat mass and improvements in insulin sensitivity without caloric restriction

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