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these symptoms may improve over time

doi: 10.1007/s00253-005-0026-6 133 PappireddiN.MartinL.WhrM

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5 These benefits might come from several factors: Weight loss itself improves mood and self-esteem Reduced inflammation (which is linked to depression) Direct effects on GLP-1 receptors in the brain Improved physical function and mobility Healthier eating habits developed while on the medication Evidence suggesting caution is needed However, a 2024 cohort study of over 162,000 patients found an association between GLP-1 medication use and increased rates of depression and anxiety diagnoses

Chronic HFD DIO studies were limited to male mice, as female mice display attenuated weight gain 28,29