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Estimands used to assess treatment efficacy In line with regulatory guidance, the STEP trials were designed to report results using two estimands

One way that regulatory agencies monitor the safety of drugs post-approval is through systems where patients and doctors can voluntarily report adverse events possibly related to a drug or medical device

Brown adipose tissue is metabolically precious, responsible for thermogenesis and energy expenditure

Diabetologia 2012;55(11):2920-2928

Lactobacillus ruteri compared with placebo as an adjuvant in quadruple therapy for Helicobacter pylori eradication: a randomized, double-blind, controlled trial

Gradual escalation does not guarantee comfort or safety