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It can't bind MC1R effectively, so melanogenesis doesn't trigger

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Alcohol enables the accumulation of ROS, thus affecting the body defense mechanisms against these products, mainly in the liver

In addition to its role as one of the regulatory metabolites for sulfur (S)-assimilating enzyme (Kopriva Citation2006), GSH and its oxidized disulfide form (GSSG) constitute an important redox couple that transfers reducing equivalents from Nicotinamide adenine dinucleotide phosphate (NADPH) to ROS (Foyer and Noctor Citation2011)