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A randomized, double-blind, placebo-controlled, parallel-group study showed that among the patients with T2DM treated with EX monotherapy, EX could improve glycated hemoglobin, fasting blood glucose, and postprandial blood glucose control, reduce weight, improve cell function, and adjust blood pressure
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Additionally, chronic versus acute allulose consumption may produce different effects, as repeated exposure could lead to adaptive changes in gut hormone secretion patterns, though longitudinal data addressing this question are currently lacking
It is contraindicated for weight management during pregnancy (Zepbound), and women of reproductive potential should be counseled about potential effects on oral contraceptive efficacy
