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No significant difference in dementia risk was observed between SGLT2 inhibitors versus GLP1 receptor agonists

Based on class data from authorised GLP-1 RA SmPCs, prescribers should consider therapeutic drug monitoring or clinical assessment when initiating retatrutide in patients taking medicines such as: Digoxin used for heart failure and atrial fibrillation

In line with our short-term metabolic analyses, previous studies in New Zealand obese and diet-induced obese male mice suggested that GLP1/E acts primarily at central levels to reverse metabolic alterations by decreasing food intake and body weight, while the potential beneficial effects on pancreatic beta-cells were possibly secondary and indirectly-mediated 33,48

Nature Medicine, 2024 Jan5;30(1):168176

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Finally, in other European markets where obesity drugs are marketed (Denmark, Norway, Spain, and Italy), reimbursement by the public insurance system is not provided