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Moreover, pathways mediating ferroptosis in breast cancer include T-cell inhibition via GCH1-BH4 [74] and ferroptosis triggered by DHODH-CoQH2 following GPX4 inactivation [75]
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Lower thresholds likely exclude individuals without pauses in medication, whereas higher thresholds more likely relate to the actual dosage that individuals receive (i.e., those with no pauses but receiving low-to-intermediate doses are excluded with these thresholds)
PMID: 6548970
doi: 10.1002/hep.29465 65
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