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Individual factors like medical history, concomitant medications, and baseline health determine the safety and appropriateness of indefinite therapy

Does the nausea mean the medication is working

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Besides the ability to regulate metabolic syndrome, including lowering glucose and lipid synthesis (50), leptin is one of the mediators responsible for the inflammatory state (51)

In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea

El-Hattab AW, Li FY, Shen J, Powell BR, Bawle EV, Adams DJ, et al