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Stanley et al., 1992

Inflammatory mechanisms in heart failure with preserved ejection fraction

6.1 Other chain-breaking ATs Probucol was primarily designed and approved for medicinal use as a cholesterol-lowering agent in the treatment of coronary artery disease, and secondarily, it may provide antioxidant activity

San Yeoh B, Gewirtz AT, Vijay-Kumar M

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Patients were excluded from the studies if they had a history of or current unstable cardiac disease or long QT syndrome, clinically significant respiratory disease other than COPD, and recent history of COPD exacerbation requiring hospitalization or need for increased treatments for COPD within 6 weeks prior to screening