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HGF/Met hepatocyte growth factor dysregulation of the HGF/Met system often leads to neoplastic changes and to cancer (in both human and animal) where it contributes to tumor formation, tumor metastasis, and tumor angiogenesis

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In these cases, the upper arm often retains a more consistent subcutaneous layer, providing a reliable alternative

Notably, no significant changes in bone turnover markers (osteocalcin, bone-specific alkaline phosphatase) were observed, indicating effects primarily through bone volume rather than remodeling markers

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