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Across the studied peptides, the authors reported reduced MMP-9 synthesis, increased Ki-67 and CD98hc expression, and, for AED and AEDG, suppression of caspase-dependent apoptosis that increased during cell-culture aging
In REDEFINE 1, Novo randomized more than 3,400 participants, all of whom had at least one weight-related comorbidity, to receive cagrilintide, semaglutide, CagriSemaa fixed-dose combination of the other two drugsor placebo
Central dopaminergic activation is considered the primary driver of these effects
Lastly, other similar drugs (empagliflozin and Orlistat) were used as a negative control to support the final conclusion
