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Med Princ Pract 29(1):15 [DOI] [PMC free article] [PubMed] [Google Scholar] Zhang L, Lu H, Xu P (2016) Effect of Huangqi capsule on the level of autoimmune antibodies in patients with Hashimotos thyroiditis

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Upon IGF-I binding, the -subunits undergo conformational change which causes activation of the internal kinase activity and autophosphorylation of the kinase domain which then phosphorylates insulin receptor substrate-1 (IRS-1)[81]