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According to our data, this could be explained by higher rates of discontinuation and lower maintenance dosages used in clinical practice, compared to randomized clinical trial settings. Gasoyan was the lead author of the study published on Tuesday in the Obesity Journal

However, clinical data were inconsistent among studies 22,23,24

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Key trial results: The mechanism is dual: afamelanotide increases eumelanin density in the skin (absorbing UV photons before they reach vulnerable cellular targets) while simultaneously activating anti-inflammatory pathways that reduce the phototoxic cascade