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Recent studies have also revealed that bile acids have endocrine functions, regulating glucose and lipid metabolism

7.6%, p = 0.369)

Infrastructure for Measurement and Early Warning These documented dependencies were visible in trade data and investigational new drug (IND) or abbreviated new drug application (ANDA) submissions for years before they reached crisis level

(31980292) Imipenem is less effective in reducing valproate metabolism, so it may not be helpful

While generally considered safe, long-term or high-dose DFO administration can still lead to neurotoxicity or organ damage (Zhang et al., 2025), and it requires slow infusion due to the risk of hypotension (Gerhardsson, 2022)

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