Conversely, ferroptosis inhibitors significantly attenuate 6-OHDA-induced neuronal damage ( /GPX4 signaling axis in the prefrontal cortex of AD mice, upregulates ferritin light chain (FTL) and -site amyloid precursor protein cleaving enzyme 1 (BACE1), downregulates 4-hydroxynonenal (4-HNE), inhibits ferroptosis and lipid peroxidation, and ameliorates cognitive deficits ( 2 Ferroptosis overview In 2003, Dolma and colleagues identified a novel compound, Erastin, through synthetic lethality screening designed to discover anticancer agents
More extensive studies may identify optimal dosages and the long-term effects of melatonin supplementation in this population
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Additionally, HNK induced the ferroptosis of acute myeloid leukemia (AML) in a non-canonical manner by significantly upregulating HO-1 expression instead of downregulating SLC7A11 expression (Lai et al., 2022)