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Retatrutide is an investigational once-weekly triple agonist targeting the GIP, GLP-1, and glucagon receptors pathways involved in appetite, satiety, glucose metabolism, and energy balance

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The shift to first-line in just a few years is significant and I believe approvals like Foundayo (orforglipron) will add to that shift

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Nocturnal awakenings may occur, sometimes associated with nausea or abdominal discomfortrecognised side effects of Wegovy