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Author contributions XZ: Methodology, Validation, Conceptualization, Investigation, Writing original draft, Formal Analysis

In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors

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456 In the spinal cord, the influx of neuropathic signals to the dorsal horn leads to central sensitization, characterized by increased spontaneous neuronal activity, lowered activation thresholds for peripheral stimuli, heightened responses to sub-threshold stimuli, and expansion of receptive fields

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