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It is not approved by the TGA for human or veterinary use and is not sold as a medicine or supplement

The Dual Agonist Advantage: GLP-1 and GIP Unlike earlier medications that targeted only one pathway, tirzepatide is a novel dual agonist, mimicking the action of two naturally occurring incretin hormones: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

Weight regain is a possibility with both medications when treatment ends, which is why obesity is increasingly treated as a chronic condition that benefits from long-term, supervised care

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No significant differences were seen for the primary outcome measure of changes in intestinal permeability as determined by urinary lactulose to mannitol ratio