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Furthermore, bacterial-derived EVs (BEVs) can be specifically recognized and internalized by phagocytic cells through pattern-recognition receptors responding to surface components like LPS or LTA 162

In 2025, among California firms that provide health benefits, 22% of those with 200 to 999 workers, 31% of those with 1,000 to 4,999 workers, and 50% of those with 5,000 or more workers cover GLP-1 agonists when used primarily for weight loss in their largest plan

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Experimental models have examined their potential involvement in appetite-related signaling, energy balance pathways, and autonomic nervous system interactions

Without human trials, clinicians cannot reliably determine appropriate dosing, long-term risks or whether benefits outweigh risks

Most patients can return to daily activities immediately after treatment