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Figure 2: Photograph of Claude Bernard, unknown date

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Detailed Category Analysis# Mechanism of Action# Amycretin : Unimolecular dual GLP-1 and amylin receptor agonist

Concurrently, the focal adhesion pathway was hyperactivated, as evidenced by the upregulated expression of key adhesion and cytoskeletal linker proteins, including Actn1 , Tln1 , and Rac2 (3.1- to 8.5-fold), suggesting enhanced cell-ECM adhesion signaling under HFD

Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies