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Some patients with ME/CFS have low Cortisol levels and improvement with low-dose Hydrocortisone has been shown in these patients

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Nrf2 transcriptionally regulates FTH1 (163, 164), and interventions like resveratrol or HO-1 activation reinforce the Nrf2/FTH1/GPX4 axis to suppress ferroptosis (165, 166)

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Under normal conditions, Nrf2 is sequestered in the cytoplasm by its inhibitor protein, Kelch-like ECH-associated protein 1 (Keap1)

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