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More recently, additional studies provided direct evidence for a pro-regenerative role of neutrophils by enhanced phagocytosis of necrotic cell debris and by promoting the conversion of monocyte-derived macrophages to the M2 phenotype [110, 120]

Future studies should optimize these management strategies and strengthen multimodal interventions to reduce complication rates and improve patient quality of life

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Am J Transl Res 11(12):74107421 Li H, Wang F, Yang M, Sun J, Zhao Y, Tang D (2021) The effect of irisin as a metabolic regulator and its therapeutic potential for obesity