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Patients were to be on a stable combined dose of metformin HCl extended-release or immediate-release (at maximum tolerated dose, with minimum dose for enrollment being 1500 mg) and a sulfonylurea (at maximum tolerated dose, with minimum dose for enrollment being 50% of the maximum recommended dose) for 8 weeks prior to enrollment

A 2024 analysis suggested 13% additional weight loss in GLP-1 plateau patients when topiramate was added, but adverse-event rates were higher

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Your doctor should recheck TSH and free T4 levels within 6 to 8 weeks of starting tirzepatide to determine whether a dose adjustment is needed

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GLP-1 drugs also called GLP-1 agonists or GLP-1 receptor agonists mimic a natural hormone in your body called glucagon-like peptide 1