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As a result, the medication may not work as expected

For patients with Crohn's disease who require weight management but cannot tolerate or are unsuitable for GLP-1 receptor agonists, several alternative approaches are available, aligned with NICE guidance on obesity management (CG189)

Absorption and Bioavailability Direct Delivery Vitamin B12 injections provide a direct delivery method, bypassing the digestive system

They are also highly relevant for patients prioritizing lean muscle retention alongside fat loss

It is a dual GIP/GLP-1 receptor agonist, meaning it activates two hormone pathways instead of one, which is what distinguishes it from single-pathway GLP-1 drugs like semaglutide

doi: 10.1016/j.arr.2022.101817 46 WangSLongHHouLFengBMaZWuYet al