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Monoclonal antibodies targeting the conserved PG portion (N-acetyl-L-isoglutamine) have been developed, which can specifically bind to PG (Huang et al., 2019)

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recently demonstrated that the catalytic activity of AOAA-modified CBS can be rescued in the presence of high concentrations of serine (Figure 4A) ( 50 ) values of 1.1 M and 8.5 M, respectively ( in vivo experiments